Anaphylaxis in Pregnancy: A Population-based Multinational European Study

Anaphylaxis in pregnancy is a rare but severe complication for both mother and infant. Population-based data on anaphylaxis are lacking from mainland European countries. This multinational study presents the incidence, causative agents, management maternal infant outcomes of pregnancy. descriptive used combination retrospective (Finnish medical registries) prospective population-based studies (UK, France, Belgium Netherlands) to identify cases anaphylaxis. Sixty-five were identified among 4,446,120 maternities (1.5 per 100,000 maternities; 95%CI 1.1-1.9). The incidence did not vary between Approximately three-quarters reactions occurred at time delivery. most common causes antibiotics 27 women (43%), anaesthetic agents 11 (17%; including neuromuscular blocking drugs, 7), which varied had very poor one seven mothers babies; case fatality rate was 3.2% (95%CI 0.4-11.0) neonatal encephalopathy 14.3% 4.8-30.3). Across Europe, related despite having multitude different antibiotic prophylaxis protocols.